The Guitar is the instrument of choice for all Blues musicians. 

There are different guitars for different styles of Blues, and most of all, there are different guitars for different sounds and tones.

Each musician should work on his guitar sound and tone until he is satisfied with the way he can express himself through his instrument. Eventually his sound becomes his signature.

When you hear all the great guitar players, you can recognize them instantly just by listening to the sound and tone of their guitars.